Little Wonders will open on August 10 in Govanhill with 28 places available for children aged two to five years old.
The Cathcart Road facility promises to educate youngsters with "an Islamic ethos".
The nursery claims it will carry out "activities and play that will help support children to gain an understanding of Islam, as well as developing thier learning at the same time so they are ready for their next journey educationally and spiritually."
The announcement on the nursery's Facebook page reads: "By the grace of Allah we shall be opening Scotland's first Islamic ethos nursery in Govanhill, Glasgow.
"We have now received our licence and are registered as an official and recognised nursery.
"Our nursery will open on Monday, August 10 2015.
"The nursery will start on this date with places for morning sessions available.
"There are a limited number of places available due to popular demand. Please ensure you apply with adequate time to ensure that your child receives a space."
The founder of the new nursery is Zoheeb Iqbal, who also set up the Alfalaah Academy in nearby Calder Street.
The move comes two years after the Glasgow Community Education Association (GCEA) bought Abbotsford House, in the Gorbals, with plans to rename the B-listed Victorian building The Islamic Institute.
GCEA had previously tried to buy the derelict Holmlea Primary building in Cathcart but the the bid failed. It would have had separate entrances for boys and girls.
Glasgow's South Side already has the Qalam Academy, in Pollokshields, run by the independent Islamic Educational Institute.
A former Islamic school in Glasgow, the Iqra Academy, closed in 2003 following criticisms of its treatment of girls.
Staff are hosting an open day for the public on Sunday, August 9 to allow parents to view the facility. It will also be open on Saturday, August 8 by appointment only.